Binary Research Group

Dr. Chen received his Ph.D. from the University of Maryland, USA in 1998. The BINARY lab (Biology, Information science and Nanotechnology Applications and Research laboratorY) was founded in Spring 2003. The mission is to provide a cross-disciplinary research environment for exploring new nanoscale device & circuit designs and nanotechnology for bio-medical applications. Our primary research focuses include:

  1. Developing a pulsed-wave technology platform to stimulate cell growth (with the applications in cell therapy, tissue engineering, mental health and antibody productions), and microorganism growth (with the applications in increasing renewable biofuel /algal oil, antibiotics, omega-3, and wine/beverage productions);
  2. Building functional nanomaterials for water filtration (removing microorganisms, organic chemicals and heavy metals), gene transformation of agricultural products, targeted cancer imaging and treatment, gene/peptide/microRNA delivery (especially across the blood-brain-barrier);
  3. Designing portable impedance-based point-of-care devices for detecting metabolic biomarkers, monitoring environmental toxins, sensing plant infections at an earlier stage, and screening pathogens for food safety.

The University of Alberta is home to cutting edge facilities such as the National Institute for Nanotechnology, as well as having the interdisciplinary expertise to be an epicentre for new waves of innovation in Biomedical Engineering. The University of Alberta was ranked 46th in the world for the impact of its engineering publications.

  
News

 
Invited speaker at IEEE-NIH 2016 Special Topics Conference on Healthcare Innovations and Point-of-Care Technologies    (01/12/2016)

Dr. Jie Chen was invited to give a talk "Desinging and Micro-nano-fabircating Portable Impedance-based Point-of-Care Biosensors" at IEEE-NIH 2016 Special Topics Conference on Healthcare Innovations and Point-of-Care Technologies, Cancun, Mexico, Nov. 11-19 (http://hipt.embs.org/2016)

"Three-Dimensional Coating of Porous Activated Carbons with Silver Nanoparticles and its Scale-up Design for Plant Disease Management in Greenhouses" was accepted by Journal of Plant Pathology & Microbiology    (10/11/2016)

Abstract: Greenhouse vegetable production is significantly impacted by pathogens that cause diseases to the roots of plants. These diseases are increasingly problematic in hydroponic vegetable production. Standard commercial practices in modern vegetable production facilities reuse the nutrient solution to reduce costs, or use dugout water for greenhouse irrigation in rural areas. This practice of recycling water may introduce or spread pathogens. Once pathogens contaminate water systems, they can spread quickly and cause dramatic losses to yield. Water filters have been used, but do not effectively kill fungi and bacteria. Therefore, better water treatment solutions are urgently needed to manage plant disease, especially for hydroponically grown vegetables. Numerous studies have demonstrated the efficacy of silver ion (Ag+) and silver-based compounds for disinfection of a wide range of harmful microorganisms. In this article, we present a new filter material based on three-dimensional (3D) silver nanoparticle (AgNP)-coated substrates for water treatment. We prepared AgNP-coated active carbon materials and tested their antimicrobial efficacy against phytopathogenic bacterial and fungal spores, such as Pseudomonas sp., and Fusarium sp. We then conducted large-scale tests in a dynamic flow setting and evaluated the effect of the filter on Pythium root rot control of hydroponically grown cucumbers. Results indicated that killing efficiencies of 3D coating were grea [ ... ]

Received the first prize award in "2016 Innobay" Innovation International Competition     (23/10/2016)

Our impedance-based biosensor design received the first-prize award in "2016 InnoBay" international innovation competition. There are over 300 projects participated in this competition. 26 finalists were seletected. After final oral presentation, we received the first prize on Oct. 14, 2016 in Zhejian Ningbo, China. 第五届杭州湾论坛举行 聚焦创新驱动下的沪甬联动发展 中国宁波网10月14日讯(记者 黄程) 日前,“上海2040城市规划”公布,将宁波杭州湾新区纳入上海大都市圈规划;不谋而合的是,今年7月,宁波 杭州湾新区全面启动沪甬合作示范区建设,并出台《全方位接轨上海三年行动计划》,在此背景下,10月14日下午,以“创新驱动下的沪甬双城联动 发展”为主题的2016第五届杭州湾论坛在宁波杭州湾新区举行,论坛从商业文明、政策环境、企业转型、创新合作、全球视野等多个角度切入,邀请 政坛要人、专家学者、知名企业家以及高新创业企业代表进行多方交流,为新区区域发展和沪甬两地城市的联动发展激荡智慧风暴、献计献策。    宁波杭州湾新区管委会主任、党工委副书记俞雷,中科院院士、复旦大学副校长、复旦大学宁波研究院院长金力在论坛开幕仪式上致辞。复旦大 学历史系教授、《百家讲坛》著名主讲人钱文忠,宁波沁园集团有限公司董事长兼总经理叶建荣,上海股 [ ... ]

QS and Times worldwide university ranking    (01/10/2016)

University of Alberta was ranked 96 according to QS (Quacquarelli Symonds) worldwide Rankings 2015 Canada Top Universities in 2015 University Location QS (Quacquarelli Symonds) World Rankings 2015 McGill University Montreal 25 University of Toronto Toronto 34 University of British Columbia Vancouver 50 University of Alberta Edmonton 96 University of Alberta was ranked 107 according to Times Higher Education worldwide Rankings 2015 Canada Top Universities in 2015 University Location QS (Quacquarelli Symonds) World Rankings 2015 University of Toronto Toronto 22 University of British Columbia Vancouver =36 McGill University Montreal 42 University of Alberta Edmonton 107

A journal paper was accepted by Biomedical Physics & Engineering Express    (05/09/2016)

A co-authored paper "A monochromatic x-ray irradiation system for in vitro studies at synchrotron beamlines", M. Niestroj, B. Bewer, D. Mousseau, D. Chapman, J. Chen and J. Hormes was accepted by Biomedical Physics & Engineering Express. Abstract: The use of synchrotron light in radiobiological keV x-ray in vitro studies has been accompanied by compromises on culture conditions and sample handling procedures. The presented monochromatic x-ray system bridges the gap between synchrotron science and cell biology by facilitating the irradiation of adherent cells uninterruptedly maintained under cell type-specific conditions throughout the entire experiment. The system for horizontal irradiations consists of a single crystal Laue monochromator, a beam monitor, and a scanning sample stage. As implemented at the BMIT-BM beamline, the system enables homogeneous cell culture irradiations with intense and purely monochromatic x-ray beams (10–30 keV). The first MCF-7 dose-response study demonstrates how the establishment of a stress-minimized experimental procedure leads to accurate and precise in vitro irradiation results. The cell survival as a function of the surface dose is well described by a first-order exponential decay, indicating that the cellular damage induced by 11.9 keV x-rays is comparable to the lethal effects caused by high linear energy transfer particles. The system design opens up the pathway for combined live-cell imaging and monochromatic keV x-ray appli [ ... ]

A journal paper was accepted by IEEE TCAS-II    (21/08/2016)

"A Fully-integrated Multistage Cross-coupled Voltage Multiplier with No Reversion Power Loss in Standard CMOS Process" by Xiaojian Yu, Kambiz Moez, I-Chy Wey, Mohammad Sawan and Jie Chen  was accepted by IEEE TCAS-II. Novelty: With the trend of integrating different modules on a monolithic system-on-chip, the demand for integrated power management with multiple output voltages is ever increasing. Among the boost converters topologies, switched-capacitor (SC) based step-up DC-DC converters are most appropriate for fully integration in CMOS technology as they do not need the large inductors required in other topologies. In this article, we propose a new structure of cross-coupled voltage multiplier and a clock scheme that eliminates all of the reversion power loss and increases the power efficiency. This design is compatible with the standard CMOS process without any overstress voltage. We implemented the design using 0.13μm IBM CMOS process with a maximum power efficiency of 88.16% and 80.2%, respectively. The maximum voltage conversion efficiency reaches 99.8% under the supply voltage of 1.2 V. 

Two invited talks at coming IEEE Engineering in Medicine and Biology Society, Florida, August 16-20, 2016    (26/07/2016)

1. Peter Hermensen, Scott MacKay, David Wishart and Jie Chen, “Simulations and Design of Microfabricated Interdigitated Electrodes for Use in a Gold Nanoparticle Enhanced Biosensor”, (invited talk in special session “Micro/Nanofabricated Devices for Biomedical Sensing and Diagnostics”), The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Florida, August 16-20, 2016 2. Xiaojian Yu, Kambiz Moez, I-Chyn Wey, Mohamad Sawan and Jie Chen, “Fully-integrated Multiple-stage Cross-coupled Voltage Multiplier for Lab-on-chip Biosensors”,  (invited talk in special session “Lab-On-Chip Based Biosensors and Actuators for Biomedical Applications”), The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Florida, August 16-20, 2016

Invited talk at the University of Toronto, Canada    (16/07/2016)

On May 19, Jie Chen was invited to give a talk about his point-of-care device design at the University of Tornoto, Canada

Elected as the Fellow of the Canadian Academy of Engineering    (10/06/2016)

Part of the acceptance letter April 13, 2016 Dear Mr. Chen The Canadian Academy of Engineering (CAE) compreises a small number of distinguished engineers from all disciplines, who have undertaken to serve the country and the profession in matters of broad concern. As President of the CAE, it is my previlege to inform you that, in recognition of your notable achievements, our Fellows have elected to offer you membership in our academy. I congratue you on this outstanding recognition! Should you accept our offer, you will be joining the most highly accomplished men and women in the field of engineering in Canada. ... The indution of new Fellows will occur during our 2016 Annaul Meeting in Winnipeg, Manitoba. The induction ceremony will take place at 18:00 hrs on Monday, June 27 at the Canadian Museum for Human Rights. I hope that you will be able to attend.   ... I look forward to welcoming you into the Canadian Academy of Engineering and to your participation in the Academy's acivities in Winnipeg this June. Yours sincerly, Pierr Lortie, FCAE President

IEEE CASS Distinguished Lecturer talks at IEEE NEW YORK chapter and Tufts University    (27/04/2016)

As a part of IEEE CASS Distinguished lecturer series 2016, Dr. Jie Chen was invited to give a talk at IEEE New York Chapter and Tufts University, Boston, USA.  He was also invited to serve as a judge for the junior student project designs at Syracuse University, USA on April 21, 2016.

NSERC Discovery Grant Renewal in Ultra-low Power Circuit and System Design    (11/04/2016)

Grant Summary: Power consumption has become a key performance criterion for integrated circuit design, especially in battery-based portable systems. Decreasing supply voltage is one of the most efficient and universal techniques to reduce energy dissipation because power is proportional to the square of supply voltage. However, when CMOS devices are scaled down following Moore’s law, noise tolerance becomes the bottleneck for the viability of nanoscale circuits. Furthermore, the smaller noise margin in low-voltage CMOS systems renders them even more sensitive to noise. Soft faults (caused by inherent noise and signal coupling) and hard faults (caused by variability and defects of fabrication technologies) present an obvious problem in nanoscale circuits. Random and dynamic noise, however, do not decrease in the same proportion as supply voltage is scaled down, which becomes a major challenge for low-supply-voltage designs. This Discovery Grant will be used to support the applicant’s ongoing Markov Random Field (MRF) research. The longterm goal is to develop a game-changing probabilistic-based methodology, which can influence future CMOS design. MRF technology is commonly used in signal processing and communication systems. Its creative extension to hardware circuits (pioneered by the applicant) is both highly innovative and with the potential for great rewards in solving intrinsic soft faults and hard faults in nanoscale circuits. His co-authored milestone [ ... ]

Jie Chen was selected as an Associated Editor for IEEE Journal of Translation Engineering in Health and Medicine    (04/04/2016)

Jie Chen was selected as an Associated Editor for IEEE Journal of Translation Engineering in Health and Medicine. It has passed the National Library of Medicine's rigorous Sceintific Quality Review for inclusion in PubMed Central (PMC). For paper submission, please go to  https://mc.manuscriptcentral.com/jtehm-embs

Jie Chen received McCalla Professorship    (19/03/2016)

Announcing the 2016-2017 McCalla Professorships It is my pleasure to announce the recipients of the 2016-2017 McCalla Professorships: • JIE CHEN (Electrical and Computer Engineering, Faculty of Engineering)
• GORDON GOW (Faculty of Extension)
• DEVEREAUX JENNINGS (Strategic Management and Organization, Alberta School of Business)
• WENDY HOGLUND (Psychology, Faculty of Arts)
• SIMON LANDHAUSSER (Renewable Resources, Faculty of Agricultural, Life and Environmental Sciences)
• KIM MISFELDT (Fine Arts and Humanities, Augustana Campus)
• RALF SCHIRRMACHER (Oncology, Faculty of Medicine and Dentistry)
• JOHN WALDRON (Earth and Atmospheric Sciences, Faculty of Science) The abstract of each McCalla Professor has been posted at: https://uofa.ualberta.ca/centre-for-teaching-and-learning/awards/mccalla-professorships. The McCalla Professorship recognizes our colleagues' outstanding contributions to the university community and their commitment to integrate teaching, research and learning throughout their careers. This award allows the recipients to further explore and implement strategies integrating their teaching and research. The namesake for the award, Arthur Gilbert McCalla, combined his research in protein chemistry with his passion for teaching, and he was instrumental in developing and expanding graduate studies. He held many senior administrative roles at the University of Alberta, and he was the first Dean of the Faculty of Graduate St [ ... ]

IEEE CAS Distinguished Lecturer 2016-2017    (03/03/2016)

Dear Jie, I am writing to you on behalf of the CAS President, Franco Maloberti and the IEEE Circuits and Systems Society. We are pleased to notify you that you have been selected as an IEEE Circuits and Systems Society Distinguished Lecturer for 2016-2017. The mission of the CAS Distinguished Lecturer Program (DLP) is to serve the needs of the members of the CAS Society to enhance their professional knowledge and vitality by keeping them informed of the latest research results and their practical applications. We are honored to have you serve in this prestigious position in CAS. All information regarding the DLP process is listed here: http://ieee-cas.org/education/inviting-a-speaker. Please let me know if you have any questions. Congratulations! Kind regards, Brittian Gimbel IEEE Circuits and Systems Society Administrator Phone +1 (352) 872-5544, ext. 302 Fax +1 (352) 872-5545

A conference paper has been accepted by 2016 IEEE Power & Energy Society General Meeting    (11/02/2016)

"Stochastic Modelling of Community Energy Storage System based on Diffusion Approximation" by Weiran Wang, Hao Liang and Jie Chen has been accepted by IEEE Power & Energy Society General Meeting, July 16-21, 2016 Boston.  Abstract:  With the high demand for renewable energy sources such as wind turbines, the future distribution systems and/or microgrids will face more challenges in energy management, due to the intermittency of renewable power generation. By buffering such uncertain power supplies, community energy storage (CES) systems can provide dispatchable capacities and are effective tools to harness renewable power in a community. However, the dispatch of a CES system is complicated due to the randomness in its state-of-charge (SoC) and thus, the randomness in dispatchable capacities. In order to address this problem, a stochastic model of CES system with wind power generation is reported in this paper. The power generation of each wind turbine is modelled using a Markov modulated rate process (MMRP), while the CES system is modelled as a queueing system with heterogeneous sources and constant output. Based on a diffusion approximation of the queue length, a closed-form representation of the cumulative distribution function (CDF) of the SoC of CES system can be derived. The analytical model is validated by a case study based on the wind power generation data obtained from Changling Wind Farm in Jilin Province of Northeast China.

An Impedance Detection Circuit for Applications in a Portable Biosensor System    (01/02/2016)

An Impedance Detection Circuit for Applications in a Portable Biosensor System (Accepted for the coming International Symposium on Circuits and Systems 2016 (http://iscas2016.org/).) Abstract— As the world’s population ages, healthcare costs become heavy burdens worldwide. Portable point-of-care diagnostic devices, such as glucose meters, can significantly reduce the costs associated with patient care. There are many of small biological molecules present in biological samples which are of interest in healthcare applications. In this paper, a simple low-cost impedance detection circuit has been designed to detect different biomolecules such as DNA, proteins and other metabolites. In particular, the impedance across an electrode will change due to the binding of target biomolecules and gold nanoparticles.  Experimental results show that the device can measure impedance changes with accuracy in the range of ±3%. (Full Paper)

Implementation of Efficient Parallel Discrete Cosine Transform Using Stochastic Logic    (22/01/2016)

Implementation of Efficient Parallel Discrete Cosine Transform Using Stochastic Logic
This paper is accepted for the coming International Symposium on Circuits and Systems 2016 (http://iscas2016.org/)
 Abstract—This paper provides a new scheme for the VLSI implementation of a parallel Discrete Cosine Transform (DCT) using stochastic logic. Stochastic computation is a number representation, which can carry out complex computations with very low hardware cost. However, the delay of data output is proportional to the length of serial sequence. We provide a new area-saving parallel DCT design to improve the system throughput by using our proposed stochastic OR-adder and OR-AND-adder. Results show the proposed parallel stochastic DCT can meet the requirement of image processing while maintaining a 5% performance difference compared to the traditional DCT implementation. Our synthesized chip design using the TSMC CMOS 130nm technology also shows that the proposed parallel stochastic DCT is at least 10 times more efficient in area and delay than that of the traditional DCT and the serial stochastic DCT. (Full paper).

Area-Efficient Partial-Clique-Energy MRF Pair Design with Ultra-Low Supply Voltage    (22/01/2016)

Area-Efficient Partial-Clique-Energy MRF Pair Design with Ultra-Low Supply Voltage
This paper is accepted for the coming International Symposium on Circuits and Systems 2016 (http://iscas2016.org/)
 Abstract—As the size of CMOS devices continues to scale down, the reliability of circuits becomes one of main challenges in low supply voltage designs. Markov Random Field (MRF) circuits, a probabilistic-based approach, can achieve higher noise immunity compared to traditional designs under conditions of ultra-low supply voltage and low threshold voltage. However, the basic MRF elements have complex structures and become a stringent factor that limits MRF-based VLSI design. In this paper, we provide a partial-clique-energy MRF (PMRF) design method, trading off the noise immunity for area efficiency. We then propose an Enhanced PMRF (EPMRF)-pair for multi-level and multi-function joint PMRF designs. The main idea is to use the joint clique energy of two complementary partial clique energies to make up performance losses. The measurement results show that, the proposed EPMRF pair can operate at 0.25 V with 10-4 dB output noise power with 5.6 dB input signal-noise ratio (SNR). With the 130 nm CMOS technology, the chip of our EPMRF based carrylook-ahead adder achieves 29% area-saving and 55% energysaving compared to existing ultra-low supply voltage fault tolerant designs.   (Full paper).  

Letter of Congratulation from the President of the Fudan University    (14/01/2016)

许宁生校长给陈颉校友当选IEEE院士的贺信

IEEE Fellow    (07/12/2015)

ECE alumnus Jie Chen was elevated to Fellow of the Institute of Electrical and Electronics Engineers. The highest grade of membership, IEEE Fellow, is attained through nomination by peers and approval by the IEEE Board of Directors for distinction in the profession. Chen was recognized for contributions to low-power and biomedical ultrasound circuits and devices. He was advised by Christine Kim Eminent Professor K. J. Ray Liu at the University of Maryland. Chen graduated with both his M.S. and Ph.D. from the Department of Electrical and Computer Engineering, completing his studies in 1998. IEEE is the world’s largest professional association dedicated to advancing technological innovation and excellence for the benefit of humanity. IEEE and its members inspire a global community through its highly cited publications, conferences, technology standards, and professional and educational activities. There are more than 425,000 IEEE members in over 160 countries around the world. IEEE members are engineers, scientists, and allied professionals whose technical interests are rooted in electrical and computer sciences, engineering, and related disciplines. Chen is professor of Electrical Engineering and an adjunct professor in the Department of Biomedical Engineering at the University of Alberta in Edmonton, AB, Canada. He is also a research officer at the National Research Council/National Institute for Nanotechnology, Canada. Dr. Chen is a Fellow of the Engineering Institute of [ ... ]

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Dr. Jie Chen