Binary Research Group

Dr. Chen received his Ph.D. from the University of Maryland, USA in 1998. The BINARY lab (Biology, Information science and Nanotechnology Applications and Research laboratorY) was founded in Spring 2003. The mission is to provide a cross-disciplinary research environment for exploring new nanoscale device & circuit designs and nanotechnology for bio-medical applications. Our primary research focuses include:

  1. Developing a pulsed-wave technology platform to stimulate cell growth (with the applications in cell therapy, tissue engineering, mental health and antibody productions), and microorganism growth (with the applications in increasing renewable biofuel /algal oil, antibiotics, omega-3, and wine/beverage productions);
  2. Building functional nanomaterials for water filtration (removing microorganisms, organic chemicals and heavy metals), gene transformation of agricultural products, targeted cancer imaging and treatment, gene/peptide/microRNA delivery (especially across the blood-brain-barrier);
  3. Designing portable impedance-based point-of-care devices for detecting metabolic biomarkers, monitoring environmental toxins, sensing plant infections at an earlier stage, and screening pathogens for food safety.

The University of Alberta is home to cutting edge facilities such as the National Institute for Nanotechnology, as well as having the interdisciplinary expertise to be an epicentre for new waves of innovation in Biomedical Engineering. The University of Alberta was ranked 46th in the world for the impact of its engineering publications.

  
News

 
"Impact of Low-intensity Pulsed Ultrasound on Transcript and Metabolite Abundance in Saccharomyces cerevisae" was accepted by Journal of Proteome Research    (04/08/2017)

"Impact of Low-intensity Pulsed Ultrasound on Transcript and Metabolite Abundance in Saccharomyces cerevisae" was accepted by Journal of Proteome Research Abstract: The interactions of ultrasound with biological materials are exploited for diagnostic, interventional, and therapeutic applications in humans and can improve productivity in industrial-scale generation of organic molecules such as biofuels, vaccines, and antibodies. Accordingly, there is great interest in better understanding the biological eff ects of ultrasound. We studied the impact of low-intensity pulsed ultrasound (LIPUS) on RNA expression and metabolism of S. cerevisiae . Although the transcript expression signature of LIPUS-treated cells does not diff er signifi cantly from that of untreated cells after 5 days, metabolomic profi ling by chemical-isotopic-labeling− liquid-chromatography− mass-spectrometry suggests that LIPUS has an impact on the pathways of pyrimidine, proline, alanine, aspartate, glutamate, and arginine metabolism. Therefore, LIPUS triggers metabolic eff ects beyond reprogramming of the core pathways of carbon metabolism. Further characterization of metabolism will likely be important for elucidation of the biological eff ects of LIPUS.

Happy Canada Day (150 birthday of Canada)    (01/07/2017)

Today is July 1, 2017. It is 150 birthday of Canada. Happy Canada Day!

A US NIH grant awarded    (24/06/2017)

Dr. Jie Chen was a co-PI of a recently awarded NIH grant " Point of care urine metabolomics test to diagnose colorectal cancer and polyps in Nigeria" led by Dr. Kingham at the Memorial Sloan Kettering Cancer Center, New York. The score of the NIH grant is 19 out 90 (10 is the best while 90 is the worst), ranked second highest among its peers in the competition. His involvement in this multiple team grant is to lead the development of the point-of-care biosensor.

Invited talk at Yale University     (08/06/2017)

On May 8, 2017, Dr. Jie Chen was invited to give a talk  "Design of a Portable Impedance-based Point-of-Care Biosensor" at Yale University. 

"Nanoformulated Water-Soluble Paclitaxel to Enhance Drug Efficacy and Reduce Hemolysis Side Effect" was published    (20/05/2017)

"Nanoformulated Water-Soluble Paclitaxel to Enhance Drug Efficacy and Reduce Hemolysis Side Effect" by Gu W., Chen J., Patra P., Yang X., Gu Q., Wei L., Acker J.P., Kong B. was published in  J. Biomater Appl. 2017.  Abstract: Surgery, chemotherapy, and radiotherapy are the three top cancer treatment modalities. Paclitaxel (PTX) is one of the most widely used chemotherapy drugs. However, its clinical applications have been significantly limited due to: (i) serious hemolysis effect of currently available commercial paclitaxel formulations and (ii) its water insolubility. An easy way to deliver paclitaxel by a new nanocarrier system using pluronic copolymers of P123/F68 and Sorbitan monopalmitate (Span 40) was reported in our previous research article. The characterization of the formulation and analysis of drug release and cellular uptake were also presented. In this article, we reported discoveries of our follow-up in vivo antitumor and in vitro hemolytic study discoveries. The experimental results showed that the nanoformulated PTX achieved much better tumor suppression performance while reducing hemolysis side effects. This newly formulated drug can significantly improve patient outcomes in cancer chemotherapy.

"A Low-Voltage Charge Pump with Improved Pumping Efficiency" was invited to submit in a special issue of IEEE Trans. on Circuits and Systems I    (01/05/2017)

Dear Authors,   Following the acceptance of your paper at International Symposium on Circuits and Systems (ISCAS) 2017 in Baltimore and the established tradition for this Symposium, it has been decided to prepare a follow-up issue in the IEEE Transactions on Circuits and Systems I: Regular Papers (TCAS-I), which is tentatively scheduled for November 2017.   Submission to the special issue is by invitation only and, to this extent, we have selected papers that have demonstrated the highest quality according to the ISCAS 2017 review process.   We are glad to inform you that your contribution (ISCAS 2017 paper ID: 1114) entitled    "A Low-Voltage Charge Pump with Improved Pumping Efficiency"   has been selected by this procedure and we would like to invite you to submit a follow-up manuscript of this paper to the special issue.   The submitted manuscripts must be a significantly more complete version of the ISCAS 2017 submission (with around at least 50% more unpublished technical material).  You must include with your submission both the .pdf of the original ISCAS 2017 paper and a letter explicitly stating the additional contributions of the TCAS-I paper relative to the original ISCAS 2017 paper.    Note that a submission to TCAS-I must be at least 8 pages long and should not exceed 12 pages. Your manuscript needs to be prepared following the authors' guidelines for TCAS-I, which are attached to this email.   [ ... ]

IEEE TBioCAS Associate Editor Certificate of Appreciation (sent on behalf of TBioCAS EiC, Mohamad Sawan)    (19/04/2017)

From: Brooke Johnson
Date: Monday, April 10, 2017 at 9:24 AM
To: Jie Chen
Cc: Brittian Parkinson
Subject: IEEE TBioCAS Associate Editor Certificate of Appreciation (sent on behalf of TBioCAS EiC, Mohamad Sawan) Dear Jie Chen, We appreciate your dedicated service as an Associate Editor for the IEEE Transactions on Biomedical Circuits and Systems. In recognition of your time and efforts, please find a Certificate of Appreciation attached below. If you'd prefer to have a physical copy of this certificate, please respond to this email with your full mailing address. --
Best regards,
Brooke Johnson
Conference Catalysts, LLC

It is a great honour for me to learn a particular piece of history    (15/03/2017)

During my recent trip to 8th IEEE Latin American Symposium on Circuits and System, Argentina 2017, I met my schoolmate (Dr. Tian Zhou) from Fudan University, Shanghai, China; Both Dr. Zhou and I had the same M.Sc. supervisor (Dr. Pushan Tang) in Fudan University. Dr. Zhou informed me that our supervisor’s advisor, Dr. Fushan Wang (王福山), is a student of the Nobel Prize winner in Physics (1932) Dr. Werner Heisenberg, who is a founder of Quantum Mechanism. Dr. Niles Bohr (Nobel Prize 1922) wrote a recommendation letter for Dr. Fusah Wang to Dr. Heisenberg. It a great honor for me to learn this piece of history.  

Jie Chen was invited to give a keynote talk at the IEEE Latin American Symposium on Circuits and Systems    (25/02/2017)

Jie Chen was invited to give a keynote talk "Designing and micro/nano-fabricating portable impedance-based point-of-care biosensors" and a tutorial talk "Engineering of Nanobiotechnological Systems" at 8th IEEE Latin American Symposium on Circuits and Systems / Bariloche, Argentina (Feb. 20-23, 2017)

“Algal Cell Response to Pulsed Waved Stimulation and Its Application to Increase Algal Lipid Production” was published in Scientific Reports.     (12/02/2017)

Generating renewable energy while sequestering CO2 using algae has recently attracted significant research attention, mostly directing towards biological methods such as systems biology, genetic engineering and bio-refining for optimizing algae strains. Other approaches focus on chemical screening to adjust culture conditions or culture media. We report for the first time the physiological changes of algal cells in response to a novel form of mechanical stimulation, or a pulsed wave at the frequency of 1.5 MHz and the duty cycle of 20%. We studied how the pulsed wave can further increase algal lipid production on top of existing biological and chemical methods. Two commonly used algal strains, fresh-water Chlorella vulgaris and seawater Tetraselmis chuii, were selected. We have performed the tests in shake flasks and 1 L spinner-flask bioreactors. Conventional Gravimetric measurements show that up to 20% increase for algal lipid could be achieved after 8 days of stimulation. The total electricity cost needed for the stimulations in a one-liter bioreactor is only one-tenth of a US penny. Gas liquid chromatography shows that the fatty acid composition remains unchanged after pulsed-wave stimulation. Scanning electron microscope results also suggest that pulsed wave stimulation induces shear stress and thus increases algal lipid production. (Full Paper)

A brief autobiography about Dr. Chen was published by Fudan University Alumni Magazine    (13/01/2017)

 A brief autobiography about Dr. Chen was published by Fudan University Alumni Magazine

Paper citation     (17/12/2016)

According to the Google Scholar (http://scholar.google.ca/citations?hl=en&;;user=kLA9_-8AAAAJ), my H-index and i10-index are 27 and 59, respectively, as of December 2016.

Invited speaker at IEEE-NIH 2016 Special Topics Conference on Healthcare Innovations and Point-of-Care Technologies    (01/12/2016)

Dr. Jie Chen was invited to give a talk "Desinging and Micro-nano-fabircating Portable Impedance-based Point-of-Care Biosensors" at IEEE-NIH 2016 Special Topics Conference on Healthcare Innovations and Point-of-Care Technologies, Cancun, Mexico, Nov. 11-19 (http://hipt.embs.org/2016)

"Three-Dimensional Coating of Porous Activated Carbons with Silver Nanoparticles and its Scale-up Design for Plant Disease Management in Greenhouses" was accepted by Journal of Plant Pathology & Microbiology    (10/11/2016)

Abstract: Greenhouse vegetable production is significantly impacted by pathogens that cause diseases to the roots of plants. These diseases are increasingly problematic in hydroponic vegetable production. Standard commercial practices in modern vegetable production facilities reuse the nutrient solution to reduce costs, or use dugout water for greenhouse irrigation in rural areas. This practice of recycling water may introduce or spread pathogens. Once pathogens contaminate water systems, they can spread quickly and cause dramatic losses to yield. Water filters have been used, but do not effectively kill fungi and bacteria. Therefore, better water treatment solutions are urgently needed to manage plant disease, especially for hydroponically grown vegetables. Numerous studies have demonstrated the efficacy of silver ion (Ag+) and silver-based compounds for disinfection of a wide range of harmful microorganisms. In this article, we present a new filter material based on three-dimensional (3D) silver nanoparticle (AgNP)-coated substrates for water treatment. We prepared AgNP-coated active carbon materials and tested their antimicrobial efficacy against phytopathogenic bacterial and fungal spores, such as Pseudomonas sp., and Fusarium sp. We then conducted large-scale tests in a dynamic flow setting and evaluated the effect of the filter on Pythium root rot control of hydroponically grown cucumbers. Results indicated that killing efficiencies of 3D coating were grea [ ... ]

Received the first prize award in "2016 Innobay" Innovation International Competition     (23/10/2016)

Our impedance-based biosensor design received the first-prize award in "2016 InnoBay" international innovation competition. There are over 300 projects participated in this competition. 26 finalists were seletected. After final oral presentation, we received the first prize on Oct. 14, 2016 in Zhejian Ningbo, China. 第五届杭州湾论坛举行 聚焦创新驱动下的沪甬联动发展 中国宁波网10月14日讯(记者 黄程) 日前,“上海2040城市规划”公布,将宁波杭州湾新区纳入上海大都市圈规划;不谋而合的是,今年7月,宁波 杭州湾新区全面启动沪甬合作示范区建设,并出台《全方位接轨上海三年行动计划》,在此背景下,10月14日下午,以“创新驱动下的沪甬双城联动 发展”为主题的2016第五届杭州湾论坛在宁波杭州湾新区举行,论坛从商业文明、政策环境、企业转型、创新合作、全球视野等多个角度切入,邀请 政坛要人、专家学者、知名企业家以及高新创业企业代表进行多方交流,为新区区域发展和沪甬两地城市的联动发展激荡智慧风暴、献计献策。    宁波杭州湾新区管委会主任、党工委副书记俞雷,中科院院士、复旦大学副校长、复旦大学宁波研究院院长金力在论坛开幕仪式上致辞。复旦大 学历史系教授、《百家讲坛》著名主讲人钱文忠,宁波沁园集团有限公司董事长兼总经理叶建荣,上海股 [ ... ]

QS and Times worldwide university ranking    (01/10/2016)

University of Alberta was ranked 96 according to QS (Quacquarelli Symonds) worldwide Rankings 2015 Canada Top Universities in 2015 University Location QS (Quacquarelli Symonds) World Rankings 2015 McGill University Montreal 25 University of Toronto Toronto 34 University of British Columbia Vancouver 50 University of Alberta Edmonton 96 University of Alberta was ranked 107 according to Times Higher Education worldwide Rankings 2015 Canada Top Universities in 2015 University Location QS (Quacquarelli Symonds) World Rankings 2015 University of Toronto Toronto 22 University of British Columbia Vancouver =36 McGill University Montreal 42 University of Alberta Edmonton 107

A journal paper was accepted by Biomedical Physics & Engineering Express    (05/09/2016)

A co-authored paper "A monochromatic x-ray irradiation system for in vitro studies at synchrotron beamlines", M. Niestroj, B. Bewer, D. Mousseau, D. Chapman, J. Chen and J. Hormes was accepted by Biomedical Physics & Engineering Express. Abstract: The use of synchrotron light in radiobiological keV x-ray in vitro studies has been accompanied by compromises on culture conditions and sample handling procedures. The presented monochromatic x-ray system bridges the gap between synchrotron science and cell biology by facilitating the irradiation of adherent cells uninterruptedly maintained under cell type-specific conditions throughout the entire experiment. The system for horizontal irradiations consists of a single crystal Laue monochromator, a beam monitor, and a scanning sample stage. As implemented at the BMIT-BM beamline, the system enables homogeneous cell culture irradiations with intense and purely monochromatic x-ray beams (10–30 keV). The first MCF-7 dose-response study demonstrates how the establishment of a stress-minimized experimental procedure leads to accurate and precise in vitro irradiation results. The cell survival as a function of the surface dose is well described by a first-order exponential decay, indicating that the cellular damage induced by 11.9 keV x-rays is comparable to the lethal effects caused by high linear energy transfer particles. The system design opens up the pathway for combined live-cell imaging and monochromatic keV x-ray appli [ ... ]

A journal paper was accepted by IEEE TCAS-II    (21/08/2016)

"A Fully-integrated Multistage Cross-coupled Voltage Multiplier with No Reversion Power Loss in Standard CMOS Process" by Xiaojian Yu, Kambiz Moez, I-Chy Wey, Mohammad Sawan and Jie Chen  was accepted by IEEE TCAS-II. Novelty: With the trend of integrating different modules on a monolithic system-on-chip, the demand for integrated power management with multiple output voltages is ever increasing. Among the boost converters topologies, switched-capacitor (SC) based step-up DC-DC converters are most appropriate for fully integration in CMOS technology as they do not need the large inductors required in other topologies. In this article, we propose a new structure of cross-coupled voltage multiplier and a clock scheme that eliminates all of the reversion power loss and increases the power efficiency. This design is compatible with the standard CMOS process without any overstress voltage. We implemented the design using 0.13μm IBM CMOS process with a maximum power efficiency of 88.16% and 80.2%, respectively. The maximum voltage conversion efficiency reaches 99.8% under the supply voltage of 1.2 V. 

Two invited talks at coming IEEE Engineering in Medicine and Biology Society, Florida, August 16-20, 2016    (26/07/2016)

1. Peter Hermensen, Scott MacKay, David Wishart and Jie Chen, “Simulations and Design of Microfabricated Interdigitated Electrodes for Use in a Gold Nanoparticle Enhanced Biosensor”, (invited talk in special session “Micro/Nanofabricated Devices for Biomedical Sensing and Diagnostics”), The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Florida, August 16-20, 2016 2. Xiaojian Yu, Kambiz Moez, I-Chyn Wey, Mohamad Sawan and Jie Chen, “Fully-integrated Multiple-stage Cross-coupled Voltage Multiplier for Lab-on-chip Biosensors”,  (invited talk in special session “Lab-On-Chip Based Biosensors and Actuators for Biomedical Applications”), The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Florida, August 16-20, 2016

Invited talk at the University of Toronto, Canada    (16/07/2016)

On May 19, Jie Chen was invited to give a talk about his point-of-care device design at the University of Tornoto, Canada

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Dr. Jie Chen